Simultaneous Effect of Resistance Training and Folate Nano-liposome on Dopamine Receptors in the Brain Hippocampus of Alzheimer’s Rats

Background: Alzheimer’s is progressive dementia with loss of nerve cells. Physical activity and the use nano-pharmaceutical supplements may prevent progression Alzheimer’s. The aim this study was to investigate effects resistance training Folate nano-liposome on expression D1 D2 receptors in hippocampal tissue rats. Methods: Thirty-three male Wistar rats at age eight weeks were prepared from Pasteur Institute randomly divided into 5 groups (healthy control, Alzheimer+resistance training, Alzheimer+Folate nano-liposomes, training+Folate nano-liposomes). induced, nano-liposomes injected as a supplement. animals anesthetized, hippocampus analyzed after last session. Eventually, one-way ANOVA test used estimate differences between (P≤0.05). Results: results showed significant difference terms mRNA (P≤0.000). Based Bonferroni post hoc test, there control group Alzheimer’s, Alzheimer’s+resistance Alzheimer’s+Folate nano-liposomes. Similarly, found Conclusion: Resistance changed content brain induction. These changes be partly due synergistic effect physical nano-pharmaceuticals preventing or reducing detrimental pathological conditions. Inflammatory factors appear associated neurotrophic during exercise neurodegenerative diseases.